A neutropenia suggesting an interaction between valacyclovir and mycophenolate mofetil.

摘要: Mycophenolate mofetil (MMF) is a drug which decreases the frequency of renal transplantation rejection. However, cytomegalovirus infections are common feature this treatment leading physicians to prescribe antiviral prophylactic drugs like valacyclovir. During association, neutropenia occur and cause adverse effect difficult define. This report presents case in woman treated with MMF As duration valacyclovir exactly corresponds duration, mycophenolate trough levels increased neutrophil count, responsibility was ascribed an examination literature for cases led suspicion interaction between may increase intracellular concentrations up haematotoxic levels. mechanism explain further research needed confirm interaction.