Autonomic control of bone formation

摘要: Bone remodeling is thought to be regulated by many factors including nutritional status, humoral factors, and biomechanical stress. However, the involvement of autonomic nervous system, mainly sympathetic system (SNS), in modulation bone beginning receive more attention. Neural innervation has been demonstrated. Both experimental clinical evidence indicated regulation metabolism. The neural pathway so far only identified link between potent leptin-dependent central control cells. An intact contributes maintenance healthy tissue. Conversely, disturbance could induce abnormal remodeling. In this chapter, we review current knowledge about role formation its association with diseases such as heterotopic ossification, ossification posterior longitudinal ligament, postmenopausal osteoporosis, adolescent idiopathic scoliosis, complex regional pain syndrome, Charcot neuro-osteoarthropathy, unloading-induced or peripheral damage, depression-induced osteoporosis. Understanding mechanism signaling may shed light on a potential treatment avenue for prevention reversal loss.