Beta-blocker use is associated with fragility fractures in postmenopausal women with coronary heart disease.

摘要: Background and aims: An association between cardiovascular disease osteoporosis is described. A number of drugs often used by patients with coronary heart disease, such as thiazides, statins beta-blockers, have shown controversial effects on bone. 1) To study the possible (CHD) bone mass density (BMD), quantitative ultrasound measurements (QUS) prevalence fragility vertebral fractures. 2) influence a drugs, statins, thiazides BMD Methods: Case-control performed 74 postmenopausal women who had recently suffered from CHD, 111 age-matched controls. was measured Dual X-Ray Absorptiometry (DXA) at lumbar spine proximal femur. Quantitative Ultrasound also heel. Vertebral fractures were diagnosed lateral, thoracic X-rays. The occurrence non-vertebral determined an examination medical records. Results: Patients CHD higher values BMI. They arterial hypertension hyperlipidemia, consequently consumption beta-blockers but not lower alcohol consumption. values, DXA femur, than controls, there no differences in or QUS heel two groups. all factures slightly to significant extent. similar In logistic analysis identify factors associated fractures, positively femoral neck inversely Conclusions: Postmenopausal femur but, despite this, show slight nonsignificant increase Beta-blockers are independently not.