CRITICAL VASOSPASM DURING FINGOLIMOD (FTY720) TREATMENT IN A PATIENT WITH MULTIPLE SCLEROSIS

摘要: We report on a woman who developed critical arterial vasospasm of the left arm within 7 days after having started treatment with Fingolimod (FTY720). is an orally administered modulator sphingosine-1-phosphate (S1P) receptor family, acting at 4 5 G protein-coupled S1P receptors. It causes reversible sequestration lymphocytes into lymph nodes, thereby inhibiting their migration to sites inflammation. currently tested in clinical trials for relapsing-remitting multiple sclerosis (RRMS). As receptors regulate numerous cellular processes different tissues, exhibits capacity induce versatile pharmacologic effects. ![][1] ### Classification evidence. This single observational study without controls; therefore, level evidence IV. ### Case report. A 41-year-old was recruited February 2007 as participant TRANSFORMS study,1 phase III trial comparing efficacy and safety oral 0.5 mg or 1.25 per day vs IM interferon β-1a patients RRMS (extension will continue only). The patient had been diagnosed according McDonald criteria years earlier. She never received any immunomodulatory drugs no relevant medical history. taking carbamazepine paroxysmal brainstem symptoms. After medication, she noticed intermittent pain fingertips her hand. physical examination normal Raynaud phenomenon suspected. … [1]: /embed/graphic-1.gif