A case of posterior reversible encephalopathy syndrome associated with gilenya(®) (fingolimod) treatment for multiple sclerosis
作者： Hans Lindå , Anders von Heijne
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摘要: We describe Posterior Reversible Encephalopathy Syndrome (PRES) in a woman with Multiple Sclerosis (MS) treated Gilenya® (Fingolimod). The first symptoms appeared after 21 months of fingolimod treatment. She experienced headache, altered mental status, cognitive deficits, seizures and visual disturbances. Not at any time during the course disease could signs infection or rheumatic disorder be detected. Test for anti-neuronal antibodies was also negative. Her bloodpressure normal. MRI showed widespread cortical subcortical changes some mass-effect temporo-occipital-parietal lobes left hemisphere. Contrast enhancement seen leptomeninges and, addition, there were no areas restricted diffusion hemorrhage. condition deteriorated until discontinued. Slowly her improved 8 months, only that remained two small, non-corresponding, right inferior scotomas. believe all symptoms, clinical findings this case can explained by considering PRES, probably rare, but serious, side-effect
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