Treatment with the sphingosine-1-phosphate analogue FTY 720 reduces loss of plasma volume during experimental sepsis in the rat.

摘要: BACKGROUND: Increased vascular leakage leading to hypovolaemia and tissue oedema is common in severe sepsis. Hypovolaemia together with formation may contribute hypoxia result multiorgan failure death. To improve treatment during sepsis, a potential therapeutic target be reduce the leakage. Substances affecting endothelial barrier are interesting this respect, as it suggested that increase depends on reorganisation of cells breakdown barrier. The agonist bioactive lipid sphingosine-1-phosphate, FTY720, has been shown modulate integrity endothelium permeability both vitro vivo. aim present study was determine if FTY720 could loss plasma volume experimental sepsis rats. METHODS: Sepsis induced by ligation incision caecum rat. Plasma determined before 4.5 h after induction dilution technique using (125) I-labelled albumin. RESULTS: dose 0.2 mg/kg reduced approximately 30% compared vehicle, without any adverse effects haemodynamic physiological parameters. hematocrit haemoglobin concentration also found higher vehicle group. CONCLUSION: side reduces most likely because reduction therefore beneficial (Less)