Evidence for the activation of the N-methyl-D-aspartate receptor during epileptiform discharge.
作者： G. L. King , R. Dingledine
DOI: 10.1007/978-1-4684-7971-3_35
关键词:
摘要: N-methyl-D-aspartate (NMDA) receptors appear to be the most easily characterized class of excitatory amino acid in central nervous system. Receptor activation by NMDA is blocked certain phosphonate compounds and sensitive extracellular Mg2+ concentration, characteristics lacking ’non-NMDA’ such as for quisqualate kainate (for review, see Watkins, 1984). Although are abundant hippocampus (Monaghan et al., 1983; Greenamyre et.al., 1985), putative antagonists have little or no effect on synaptic transmission this structure under normal conditions (see Coan Collingridge, 1985). Several investigators therefore suggested that activated abnormal unusual (Harris 1984; 1985; Crunelli For example, prevent long-term potentiation (Collingridge 1983b), protect against CNS ischemia (Simon 1984) suppress some seizures Meldrum, In addition, iontophoretic application onto either mammalian neocortical caudate neurons produces a pattern burst discharge similar observed an epileptic focus (Flatman Herrling 1983).
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