Chemical approaches to control gene expression.
作者： J.M. Gottesfeld , J.M. Turner , P.B. Dervan
DOI: 10.3727/000000001783992696
关键词:
摘要: A current goal in molecular medicine is the development of new strategies to interfere with gene expression living cells hope that novel therapies for human disease will result from these efforts. This review focuses on small-molecule or chemical approaches manipulate by modulating either transcription messenger RNA-coding genes protein translation. The molecules under study include natural products, designed ligands, and compounds identified through functional screens combinatorial libraries. cellular targets DNA, RNA, components transcription, RNA processing, translational machinery. Studies model systems have shown promise inhibition both viral mRNA utilization. Moreover, repression activation been described. These studies offer treatment diseases pathogenic (viral, bacterial, etc.) origin (cancer, genetic diseases, etc.).
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