Posterior parietooccipital hypometabolism may differentiate mild cognitive impairment from dementia in Parkinson’s disease

摘要: Patients with Parkinson’s disease (PD) may have normal cognition, mild cognitive impairment (MCI) or dementia. We investigated differences in cerebral metabolism associated these three states and the relationship between dysfunction. FDG PET a battery of neuropsychological tests were used to study PD patients dementia (n = 19), MCI (n = 28) cognition (n = 21), control subjects (n = 20). Regional glucose controls was analysed using statistical parametric mapping (SPM8) corrected for age, motor severity depression. Correlations mini-mental state examination score Z-score values different domains respect uptake assessed SPM8. (PD-MCI patients) exhibited decreased frontal lobe, lesser extent parietal areas compared cognitively patients. showed reduced parietal, occipital temporal less extensive reduction lobe PD-MCI patients, while widespread hypometabolism seen comparison cognition. lobes localized controls, whereas cortical metabolism. Mini-mental correlated positively several lobes, executive function parietooccipitotemporal junction memory temporoparietal metabolism, visuospatial occipitoparietal language regions Hypometabolism higher than those MCI, mainly posterior where it visuospatial, functions.