From the Medical Board of the National Psoriasis Foundation: monitoring and vaccinations in patients treated with biologics for psoriasis.

摘要: Background Biologics are widely used in the treatment of psoriasis and psoriatic arthritis. Objective Our aim was to arrive at a consensus on kind monitoring vaccinations that should be performed before during biologic therapy. Methods Medical literature data presented meetings were reviewed conference held by members Board National Psoriasis Foundation. Results Consensus established vaccination practices included discussion recognition variations those practices. History, physical examination, chemistry screen with liver function tests, complete blood cell count, platelet count tuberculosis testing obtained baseline variable frequencies thereafter. Patients treated efalizumab have counts checked more often; tests repeated frequently patients infliximab; taking tumor necrosis factor blockers undergo alefacept CD4 approximately every 2 weeks. Avoidance live vaccines therapy administration essential discussed, although is only degree. There no consistency measurement antinuclear antibodies among experts. Limitations few evidence-based studies for therapies. Conclusions In therapies psoriasis, chemistries, counts, antibodies, tuberculin skin history, examination may warranted depending particular patient. Vaccination also addressed.