Mechanical stress-induced apoptosis of nucleus pulposus cells: an in vitro and in vivo rat model
作者： Yi-Jie Kuo , Lien-Chen Wu , Jui-Sheng Sun , Ming-Hong Chen , Man-Ger Sun
DOI: 10.1007/S00776-013-0510-2
关键词:
摘要: Background Un-physiological loads play an important role in the degenerative process of inter-vertebral discs (IVD). In this study, we used vitro and vivo rat model to investigate mechanism nucleus pulposus (NP) cells apoptosis induced by mechanical stress.
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François Rannou, Tzong-Shyuan Lee, Rui-Hai Zhou, Jennie Chin, Jeffrey C. Lotz, Marie-Anne Mayoux-Benhamou, Jacques Patrick Barbet, Alain Chevrot, John Y.-J. Shyy, Intervertebral Disc Degeneration The American Journal of Pathology. ,vol. 164, pp. 915- 924 ,(2004) , 10.1016/S0002-9440(10)63179-3
Y.-H. Tsuang, Y.-S. Lin, L.-T. Chen, C.-K. Cheng, J.-S. Sun, Effect of dynamic compression on in vitro chondrocyte metabolism. International Journal of Artificial Organs. ,vol. 31, pp. 439- 449 ,(2008) , 10.1177/039139880803100510
Howard S. An, Kenji Takegami, Hiroshi Kamada, Cahn M. Nguyen, Eugene J-M.A. Thonar, Kern Singh, Gunnar B. Andersson, Koichi Masuda, Intradiscal Administration of Osteogenic Protein-1 Increases Intervertebral Disc Height and Proteoglycan Content in the Nucleus Pulposus in Normal Adolescent Rabbits Spine. ,vol. 30, pp. 25- 32 ,(2005) , 10.1097/01.BRS.0000148002.68656.4D
Wolfgang Ertel, Andreas Oberholzer, Christoph-E Heyde, Sven K Tschoeke, Markus Hellmuth, Arwed Hostmann, Trauma induces apoptosis in human thoracolumbar intervertebral discs. BMC Clinical Pathology. ,vol. 6, pp. 5- 5 ,(2006) , 10.1186/1472-6890-6-5
Yoshiyuki Imai, Kei Miyamoto, Howard S. An, Eugene J.-M. A. Thonar, Gunnar B. J. Andersson, Koichi Masuda, Recombinant human osteogenic protein-1 upregulates proteoglycan metabolism of human anulus fibrosus and nucleus pulposus cells. Spine. ,vol. 32, pp. 1303- 1309 ,(2007) , 10.1097/BRS.0B013E3180593238
SHIMPEI MIYAMOTO, KAZUO YONENOBU, KEIR OONO, Experimental cervical spondylosis in the mouse. Spine. ,vol. 16, pp. 495- 500 ,(1991) , 10.1097/00007632-199110001-00008
K P Pritzker, Animal models for osteoarthritis: processes, problems and prospects. Annals of the Rheumatic Diseases. ,vol. 53, pp. 406- 420 ,(1994) , 10.1136/ARD.53.6.406
Harris Pratsinis, Dimitris Kletsas, PDGF, bFGF and IGF-I stimulate the proliferation of intervertebral disc cells in vitro via the activation of the ERK and Akt signaling pathways European Spine Journal. ,vol. 16, pp. 1858- 1866 ,(2007) , 10.1007/S00586-007-0408-9
Fan Ding, Zeng-Wu Shao, Shu-Hua Yang, Qiang Wu, Fei Gao, Li-Ming Xiong, Role of mitochondrial pathway in compression-induced apoptosis of nucleus pulposus cells Apoptosis. ,vol. 17, pp. 579- 590 ,(2012) , 10.1007/S10495-012-0708-3
Jae-Sung Kim, Michael B. Ellman, Howard S. An, Andre J. van Wijnen, Jeffrey A. Borgia, Hee-Jeong Im, Insulin-like growth factor 1 synergizes with bone morphogenetic protein 7-mediated anabolism in bovine intervertebral disc cells. Arthritis & Rheumatism. ,vol. 62, pp. 3706- 3715 ,(2010) , 10.1002/ART.27733