Assessment of genetic diversity in IL-6 and RANTES promoters and their level in Saudi coronary artery disease patients.
作者： Nasimudeen R. Jabir , Chelapram K. Firoz , Mohammad A. Kamal , Ghazi A. Damanhouri , Mohammed Nabil Alama
DOI: 10.1002/JCLA.22092
关键词:
摘要: Background The present study consisted of a total 200 subjects (100 confirmed coronary artery disease (CAD) patients), both men and women, 100 healthy control individuals. Methods Serum concentration IL-6 RANTES were measured by enzyme-linked immunosorbent assay kit. For SNPs analysis, sanger method DNA sequencing was followed. Results We observed variable numbers SNP sites at -174 G/C, -572 G/C, -597 G/A in -28 C/G -109 C/T promoters CAD patients compared with individuals. However, the changes number found to be non-significant The level significantly (P<.001) elevated control. Moreover, serum did not show any significant change patients. Conclusion Based on our result, it is quite clear that inflammation has role pathogenesis but does lead genetic population. As far as knowledge goes, this first report shows diversity their respective levels Saudi patients.
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