The role of platelets in the recruitment of leukocytes during vascular disease.

摘要: Besides their role in the formation of thrombus during haemostasis, it is becoming clear that platelets contribute to a number other processes within vasculature. Indeed, integrated function thrombotic and inflammatory systems, which results platelet-mediated recruitment leukocytes, now considered be great importance propagation, progression pathogenesis atherosclerotic disease arteries. There are three scenarios by can interact with leukocytes: (1) when adhere activated on sub-endothelial matrix proteins exposed vascular damage then recruit leukocytes growing thrombus. (2) Platelets stimulated endothelial cells bridge blood borne vessel wall and. (3) Adhesion between occurs leading heterotypic aggregates prior contact cells. In following review we will not discuss leukocyte as this represents physiological response tissue trauma progress, at least its early stages, absence inflammation. Rather deal 2 3, these pathways platelet–leukocyte interactions important inflammation chronic diseases such atherosclerosis. mean possess means adhesion under conditions may normally permissive leukocyte–endothelial cell adhesion, meaning process able bypass regulatory would ordinarily moderate response.