Controlled Release of Ropivacaine from Single-Armed (1-PCL) and Four-Armed PCL (4-PCL) Microspheres

摘要: Sustained release of anesthesia has shown great promise in the treatment chronic pain patients. In this research, we used neutralized ropivacaine as an and poly(e-caprolactone) (PCL) with different architectures to systematically study how these affect ropivacaine. After optimizing parameters preparation microspheres, ropivacaine-loaded 1-PCL microspheres 4-PCL were obtained. Fourier Transform infrared spectra (FT-IR) X-ray diffraction (XRD) confirmed that was encapsulated within microsphere rather than inserted on surface microsphere. Ropivacaine found be buried deeper vitro assay revealed small crystalline grains interfered during initial period, but then two kinds showed a similar rate. We basically proved architecture PCL negligible effect release. Cell proliferation test products from resulted insignificant toxicity towards mammalian cells.