Osteogenic sarcoma. Malignant fibrous histiocytoma subtype

摘要: A distinctly different entity from the now well-delineated malignant fibrous histiocytoma (MFH) of bone is MFH histopathologic subtype osteogenic sarcoma. Although uncommon, recently authors have encountered six cases this neoplasm, in each which soft tissue component was devoid elements and microscopically indistinguishable or tissue. Neoplastic osteoid woven were present osseous tumor, however. Radiologically, lesions generally osteoblastic but focally osteolytic with features typical Pain most common presenting symptom. There no age sex predilection. Immunocytochemical staining showed strong positivity alpha-1-antichymotrypsin within bizarre giant cells occasional neoplastic osteoblasts five cases. The biological behavior followed a very aggressive course. Four patients developed pulmonary metastases 6 to 12 months after initial surgery; one patient presented initially metastases. Adequate tumor sampling as well optimal correlation clinical radiographic information are required distinguish sarcoma bone, both being high-grade neoplasms,