The cloning and sequencing of a ribosomal L18 protein from an evolutionary divergent eukaryote,Trypanosoma brucei
作者： Lesley J. Coulter , Geoff Hide
DOI: 10.1016/S0167-4781(96)00144-3
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摘要: Eukaryotic ribosomal proteins are highly conserved across widely divergent species, suggesting that strong functional constraints prevent divergence of important amino acid motifs. Using this as a basis, an evolutionary approach could be used to identify putative We obtained the DNA sequence protein L18 from protozoan parasite, Trypanosoma brucei. Analysis showed it had 46% and 43% identity with human yeast sequences, respectively, 30% residues were identical all species analysed. these data, acids essential structure function can inferred provide valuable information for molecular modelling mutational studies.
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