Blood pressure and blood selenium: a cross-sectional and longitudinal population study.

摘要: Aims Western Europeans have low blood levels of selenium (BSe), an antioxidant trace element. In a Flemish population, we investigated the cross-sectional and longitudinal association pressure (BP) with BSe. Methods results We randomly recruited 710 subjects (mean age 48.8 years; 51.8% women). measured BP BSe kept participants in follow-up for BP. At baseline, systolic/diastolic averaged (SD) 130/77 (17.3/9.2) mmHg. was 97.0 (19.0) µg/L. Of 385 normal baseline (<130 <85 mmHg), over 5.2 years (range 3.4–8.4 years), 139 developed high-normal (130–139/85–90 mmHg) or hypertension (≥140/90 mmHg). multivariate-adjusted analyses men, 20 µg/L (∼1 SD) higher associated lower effect sizes 2.2 mmHg systolic (95% CI −0.57 to −5.05; P = 0.009) 1.5 mmHg diastolic −0.56 −2.44; 0.017). prospective 37% −52 −17; 0.001) risk developing hypertension. None these associations significant women. Conclusion Deficiency might be underestimated factor development high European men.