Association between mortality and serum uric acid levels in non-diabetes-related chronic kidney disease: An analysis of the National Health and Nutrition Examination Survey, USA, 1999-2010.

摘要: The relationship between serum uric acid (SUA) and cardiovascular (CV) mortality in patients with chronic kidney disease (CKD) has been described as either a J- or U-shaped function. However, its effect non-diabetic CKD (and varying severities of CKD) remains unclear. We analyzed the database National Health Nutrition Examination Survey, USA, from years 1999 to 2010. then grouped subjects into 4 categories according their SUA levels: (a) < 5 mg/dl, (b) 5-7 (c) 7-9 mg/dl (d) ≥ 9 mg/dl. For comparison purposes (CV related, cancer related all-cause mortality), we set group reference. also separated this population moderate (stage 3) severe (stages 5) CKD. A total 1860 participants were included study. Results showed that lowest levels (< mg/dl), least male gender (19.25%), had body mass index (26.41(95% CI = 25.66-27.16) kg/m2), highest systolic blood pressure (139.02 (95% 135.72-142.32) mmHg), high-density cholesterol (59.55 57.37-61.74) glucose (95.46 93.16-97.76) (210.31 203.36-217.25) albumin (4.09 4.04-4.14) g/dl), estimated glomerular filtration rate (eGFR) (47.91 45.45-50.49) ml/min/1.732m2), history hypertension (54.4%), energy intake (1643.7 1536.13-1751.27) kcal/day). In higher (HR 2.15) whatever baseline CVD status. non-DM history, 5.39), 8.18) 8.25) mortality. (eGFR 30 significantly increased On contrary, 30-60 ml/min/1.832m2), CKD, is associated once progressing (even though it risk factors for metabolic syndrome).