Dihydropyrazoles containing morpholine: design, synthesis and bioassay testing as potent antimicrobial agents

摘要: A series of dihydropyrazole derivatives containing morpholine was designed and synthesized as antimicrobial agents. All the compounds were characterized by 1H-NMR MS. Afterwards they evaluated for in vitro antibacterial activity against four bacteria strains. Along with S. aureus TyrRS inhibition cytotoxicity examination, some proved to be low toxicity potent, especially Gram-positive Compound 4s exhibited potential new a drug strong broad-spectrum enzyme inhibitory activity. Docking simulation performed position compound into structure active site investigate probable binding mode. 3D-QSAR model also established explain how structural alterations affect guide further study.