Human neurons generate C-reactive protein and amyloid P: upregulation in Alzheimer’s disease
作者： Koji Yasojima , Claudia Schwab , Edith G. McGeer , Patrick L. McGeer
DOI: 10.1016/S0006-8993(00)02970-X
关键词:
摘要: C-reactive protein (CRP) and amyloid P (AP) are pentraxins which associated with many pathological lesions, including the deposits neurofibrillary tangles (NFTs) of Alzheimer disease (AD). It has always been assumed that they generated by liver delivered to their sites action serum. Here we report in situ hydridization, reverse transcriptase-polymerase chain reaction analysis, Western blotting immunohistochemistry mRNAs proteins both CRP AP concentrated pyramidal neurons upregulated affected areas AD brain. Controlling pentraxin production at tissue level may be important reducing inflammatory damage AD.
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M. L. Shelanski, E. Castano, F. Prelli, B. Frangione, M. Larrondo-Lillo, F. Coria, S. Van Duinen, Isolation and characterization of amyloid P component from Alzheimer's disease and other types of cerebral amyloidosis. Laboratory Investigation. ,vol. 58, pp. 454- 458 ,(1988)
Kamyar Zahedi, Characterization of the Binding of Serum Amyloid P to Laminin Journal of Biological Chemistry. ,vol. 272, pp. 2143- 2148 ,(1997) , 10.1074/S0021-9258(19)78482-8
S. Buysmann, M. C. Brouwer, I. J. M. Ten Berge, G. J. Wolbink, C. E. Hack, CRP-MEDIATED ACTIVATION OF COMPLEMENT IN VIVO : ASSESSMENT BY MEASURING CIRCULATING COMPLEMENT-C-REACTIVE PROTEIN COMPLEXES Journal of Immunology. ,vol. 157, pp. 473- 479 ,(1996)
Q Dong, J R Wright, Expression of C-reactive protein by alveolar macrophages. Journal of Immunology. ,vol. 156, pp. 4815- 4820 ,(1996)
C Mold, L Saunero-Nava, P S Hicks, T W Du Clos, Serum amyloid P component binds to histones and activates the classical complement pathway. Journal of Immunology. ,vol. 149, pp. 3689- 3694 ,(1992)
T. Duong, E. C. Pommier, A. B. Scheibel, Immunodetection of the amyloid P component in Alzheimer's disease. Acta Neuropathologica. ,vol. 78, pp. 429- 437 ,(1989) , 10.1007/BF00688180
Marcelle R. Morrison, W.Sue T. Griffin, The isolation and in vitro translation of undegraded messenger RNAs from human postmortem brain Analytical Biochemistry. ,vol. 113, pp. 318- 324 ,(1981) , 10.1016/0003-2697(81)90083-X
M Stearman, H J Southgate, The use of cytokine and C-reactive protein measurements in cerebrospinal fluid during acute infective meningitis. Annals of Clinical Biochemistry. ,vol. 31, pp. 255- 261 ,(1994) , 10.1177/000456329403100307
Laurence B. Lovat, Anthony A. J. OʼBrien, Sally F. Armstrong, Sheril Madhoo, Christopher J. Bulpitt, Martin N. Rossor, Mark B. Pepys, Philip N. Hawkins, Scintigraphy with 123I-serum amyloid P component in Alzheimer disease. Alzheimer Disease & Associated Disorders. ,vol. 12, pp. 208- 210 ,(1998) , 10.1097/00002093-199809000-00014
Koji Yasojima, Claudia Schwab, Edith G. McGeer, Patrick L. McGeer, Up-regulated production and activation of the complement system in Alzheimer's disease brain. American Journal of Pathology. ,vol. 154, pp. 927- 936 ,(1999) , 10.1016/S0002-9440(10)65340-0