Preparation, biological activity and endogenous occurrence of N6-benzyladenosines.

摘要: Cytokinin activity of forty-eight 6-benzyladenosine derivatives at both the receptor and cellular levels as well their anticancer properties were compared in various vitro assays. The compounds prepared by condensation 6-chloropurine riboside with corresponding substituted benzylamines characterized standard collection physico-chemical methods. majority synthesized exhibited high all three cytokinin bioassays used (tobacco callus, wheat leaf senescence Amaranthus bioassay). highest activities observed bioassay. For several tested, significant differences found between used, indicating that diverse recognition systems may operate. This suggests it be possible to modulate particular cytokinin-dependent processes specific compounds. In contrast bioassays, tested recognized only very low sensitivity Arabidopsis thaliana AHK3 AHK4 also investigated for antiproliferative on cancer normal cell lines. Several them showed strong cytotoxic against On other hand, they not murine fibroblast (NIH/3T3) line. ribosides important, given occur endogenous different organisms.