Massive hepatocellular [correction of hepatocullular] necrosis: was it caused by Orlistat?

摘要: Orlistat (tetrahydrolipostatin) is a lipase inhibitor which used, in conjunction with appropriate dietary control, for the treatment of obesity. It generally deemed to be safe drug, mainly exerts topical action on stomach and small bowel, negligible systemic absorption oral bioavailability. Consequently, its adverse effects have largely been limited relatively mild gastrointestinal disorders. However, there recent, published reports non-fatal acute hepatitis hypertension associated use. The present case concerns 62-year-old male who died from massive hepatocellular necrosis, consistent drug-induced, fulminant hepatitis, use orlistat, presumably administered at recommended daily dose 360 mg. postulated that this may represent rare idiosyncratic reaction drug.