Secondary Resistance to Erlotinib: Acquired T790M Mutation and Small-Cell Lung Cancer Transformation in the Same Patient
作者： Vincent Fallet , Anne-Marie Ruppert , Virginie Poulot , Roger Lacave , Laure Belmont
DOI: 10.1097/JTO.0B013E31824FEA45
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摘要: CASE REPORT A 44-year-old woman a former smoker, presented with 2-month history of progressive dyspnea. Computed tomography (CT)-scan showed diffuse alveolar opacities and micronodules in both lungs. Bronchoscopy was macroscopically normal, bronchial biospsies were negative. Bronchioloalveolar lavage displayed revealed many TTF1 positive adenocarcinomatous cells harboring an exon 19 deletion (E746-A750) endothelial growth factor receptor (EGFR) gene by sequencing. No extrathoracic metastases detected on brain CT-scan or positron emission scan. first-line chemotherapy carboplatin (area under the curve = 6), paclitaxel (175 mg/ m) bevacizumab (15 mg/kg) every 3 weeks started December 2009. After stabilization at three cyles, patient pulmonary progression six cycles. Erlotinib (150 mg/day) June 2010 (Fig. 1A). partial
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