Anteroventral third ventricle lesions impair cardiovascular responses to intravenous hypertonic saline infusion.
作者： Gustavo Rodrigues Pedrino , Celisa Tiemi Nakagawa Sera , Sérgio Luiz Cravo , Débora Simões de Almeida Colombari
DOI: 10.1016/J.AUTNEU.2004.09.005
关键词:
摘要: The anteroventral third ventricle (AV3V) region is a critical area of the forebrain, acting on fluid and electrolyte balance maintaining cardiovascular homeostasis. purpose this study was to determine effects lesions responses intravenous hypertonic saline (HS) infusion. Male Wistar rats were anesthetized with urethane. femoral artery jugular vein cannulated record mean arterial pressure (MAP) infuse (3M NaCl, 0.18 mL/100 g bw, over 1 min), respectively. Renal blood flow (RBF) recorded by ultrasonic transit-time probes. vascular conductance (RVC) calculated as renal ratio expressed percentage baseline. After infusion in sham animals, increased 137+10% 125+7% (10 141F10% 133F10% (60 Increases (20-min peak: 12F3 mm Hg) also observed. An acute lesion AV3V (DC, 2 mA 25s) 30 min before abrogated saline. Mean unchanged 107F7% 103F6% 107F4 106F4% Marked tachycardia observed immediately after lesion. Responses chronic or lesioned similar those animals. However, rats, induced sustained hypertension. These results demonstrate that integrity essential for vasodilation follows changes extracellular compartment composition. D 2004 Elsevier B.V. All rights reserved.
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