Polyunsaturated fatty acids, inflammation, and immunity.

摘要: The fatty acid composition of inflammatory and immune cells is sensitive to change according the diet. In particular, proportion different types polyunsaturated acids (PUFA) in these readily changed, this provides a link between dietary PUFA intake, inflammation, immunity. n-6 arachidonic (AA) precursor prostaglandins, leukotrienes, related compounds, which have important roles inflammation regulation Fish oil contains n-3 eicosapentaenoic (EPA). Feeding fish results partial replacement AA cell membranes by EPA. This leads decreased production AA-derived mediators. addition, EPA substrate for cyclooxygenase lipoxygenase gives rise mediators that often biological actions or potencies than those formed from AA. Animal studies shown altered lymphocyte function suppressed proinflammatory cytokines macrophages. Supplementation diet healthy human volunteers with oil-derived monocyte neutrophil chemotaxis cytokines. feeding has been ameliorate symptoms some animal models autoimmune disease. Clinical reported supplementation beneficial effects rheumatoid arthritis, bowel disease, among asthmatics, supporting idea are anti-inflammatory immunomodulatory.