Impaired nocturnal melatonin secretion in non-dipper hypertensive patients.

摘要: BACKGROUND Melatonin plays a role in the biologic regulation of circadian rhythms, including sleep. has also been shown to modulate vascular smooth muscle tone and induce hemodynamic effects humans. OBJECTIVE To evaluate whether melatonin rhythm blood pressure hypertensive patients. METHODS Sixteen elderly patients with essential hypertension were evaluated. Patients defined as either dippers (DIP, n = 8) or non-dippers (NDIP, according nocturnal change mean arterial (MAP). 6-Sulfatoxymelatonin (6-SMT), main metabolite, was determined by enzyme-linked immunosorbent assay (ELISA) two separate urine collections, one daytime during night. RESULTS Both groups DIP NDIP hypertensives comparable regard age sex. During night, decreased 10.3 +/- 2.2% increased 7.5 1.7% group (p < 0.01). Daily 6-SMT (3.28 0.87 microg/12 h) (2.31 0.68 0.39). However, while presented physiological increase urinary (mean 8.19 1.68 microg/ 12 h), this surge production missing whom concentrations not significantly different from daily levels 2.56 0.79 h). The excretion positively correlated MAP (R 0.54; p 0.031). CONCLUSIONS differ having an impaired secretion. Thus, may play