摘要: Cyclo-oxygenase-2 (COX-2) is an enzyme catalysing the synthesis of prostaglandins (PGs) from arachidonic acid. Cells contain genes coding for two isoforms COX (COX-1 and COX-2). COX-1 expressed constitutively in most tissues appears to be responsible production PGs that mediate normal physiological functions, such as maintenance integrity gastric mucosa regulation renal blood flow. In contrast, COX-2 undetectable tissues: it induced by cytokines, growth factors, oncogenes tumour promoters, contributes inflamed neoplastic [1]. many human tumours associated with aberrant angiogenesis a number pathological settings, especially those involving inflammation. It has been well demonstrated dysregulation expression correlates development gastrointestinal cancers.
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