Effect of the specific cyclooxygenase-2 inhibitor meloxicam on tumour growth and cachexia in a murine model
作者： H.J. Hussey , M.J. Tisdale
DOI: 10.1002/1097-0215(20000701)87:1<95::AID-IJC14>3.0.CO;2-D
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摘要: The effects of the cyclooxygenase-2 (COX-2) inhibitor, meloxicam, on tumour growth and cachexia have been determined in 2 established murine adenocarcinomas (MAC). At a dose level 2.5 5.0 mgkg(-1), meloxicam produced pronounced inhibition MAC13 tumour, increasing volume doubling time from to 5 days. Meloxicam also suppressed MAC16 which is generally refractory standard cytotoxic agents, 1.5 days at levels 0.5 1.0 mgkg(-1). Cachexia was effectively attenuated these levels. To investigate whether exerted direct effect cachectic process, studies protein degradation were carried out using C(2)C(12) mouse myoblasts response proteolysis-inducing factor (PIF). PIF maximum concentration 4.2 nM, this by concentrations greater than 1 microM. This suggests that may be capable directly antagonizing process muscle catabolism cachexia.
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