Antibiotic-impregnated calcium phosphate cement as part of a comprehensive treatment for patients with established orthopaedic infection.

摘要: Abstract Background The treatment of established orthopaedic infection is challenging. While the main focus wide surgical debridement, systemic and local antibiotic administration are important adjuvant therapies. Several reports have described clinical use antibiotic-impregnated calcium phosphate cement (CPC) to provide therapy for bone infections. However, these were all individual case reports, no series been reported. We report a treated by single surgeon using CPC as part comprehensive plan in patients with infection. Methods enrolled 13 consecutive osteomyelitis ( n  = 6) or infected non-union  = 7). Implantation was performed that also included therapy, subsequent second-stage reconstruction surgery. investigated rate successful eradication systemic/local complications. concentration antibiotics drainage fluids, blood, recovered (via elution into phosphate-buffered saline bath) measured. Results mean follow-up period after surgery 50.4 (range, 27–73) months. There cases recurrence during follow-up. No toxicity complications from implantation observed. vancomycin fluid 527.1 ± 363.9 μg/mL on postoperative day 1 224.5 ± 198.4 μg/mL 2. In who did not receive  = 3), maximum serum level In vitro observed surgically retrieved  = 2). Conclusions an option plan.