Hepatic Progenitors of the Liver and Extra-Hepatic Tissues

摘要: The liver has a tremendous capacity to regenerate at all developmental stages (for reviews, see (1-3)). Liver cell mass can be restored even after repeated partial hepatectomies as well toxic injury. contribution of stem cells these processes is still under debate. Adult have been shown tissue repeatedly when transplanted serially (4). However, hepatocytes cannot considered because they are unipotent glossary terms, Table 1). This chapter describes various progenitors that found by different researchers in humans and other mammalian species. Intra extra-hepatic discussed give rise lineages. Intra-hepatic non-hepatic lineages, such endothelial or hematopoietic restricted progenitors, not discussed. Although the focus this on characterized normal, non-pathological conditions liver, oval will described briefly.