Drug level monitoring of antiasthmatic drugs.

摘要: Abstract In general assays pertaining to drug level monitoring (DLM) of antiasthmatic agents (except theophylline), published during the period 1978-1983, used mostly high-performance liquid chromatographic (HPLC) methodology (approximately 45%) with mass spectrometric (MS) based in second place 30%) followed by immunochemical techniques 25%). Whenever nanogram or subnanogram concentrations had be measured such as for adrenergic stimulants prophylactic agents, then both HPLC- and MS-based methodologies were employed about equal frequency. The trend DLM phosphodiesterase inhibitor class (theophyllines) seemed shifting towards HPLC methodologies. part this was justified need improved selectivity. This criterion appears have been better satisfied HPLC, but all practical purposes methods are will probably continue prevail clinical laboratory setting until procedures become truly automated. case corticosteroids asthmatic, situation is our opinion still unclear. caused presence endogenous metabolites, levels which man known vary. current offer a facile less selective option. future routine corticosteroid may well gas chromatography coupled MS.