Double-blind cluster randomised controlled trial of wheat flour chapatti fortified with micronutrients on the status of vitamin A and iron in school-aged children in rural Bangladesh

摘要: Food fortification is a cost-effective and sustainable strategy to prevent or correct micronutrient deficiencies. A double-blind cluster (bari) randomised controlled trial was conducted in rural community Bangladesh evaluate the impact of consumption chapatti made micronutrient-fortified wheat flour for 6 months by school-aged children on their vitamin A, haemoglobin iron status. total 43 baris (group households) were randomly selected. The assigned either intervention control group. group received fortified with added micronutrients (including 66 mg hydrogen-reduced elemental 3030 μg retinol equivalent as retinyl palmitate per kilogram flour), while without micronutrients. 352 enrolled trial, 203 149 Analyses carried out who completed study (191 143 group). Micronutrient-fortified significantly increased serum concentration at 0.12 μmol L(-1) [95% confidence interval (CI): 0.06, 0.19; P < 0.01]. odds deficiency lower 3 [odds ratio (OR) = 0.26; 95% 0.07, 0.89; P < 0.05] (OR = 0.21; CI: 0.68; P < 0.01). No demonstrable effect status, levels anaemia observed. Consumption chapattis demonstrated significant improvement but not iron,