Maropitant citrate for treatment of ulcerative dermatitis in mice with a C57BL/6 background

摘要: Murine ulcerative dermatitis (UD) is a common progressive condition of mice with C57BL/6 background. Typically, present scabs and crusts on the skin dorsal neck ears, are often severely pruritic. Animals tend to scratch lesions, causing additional trauma already ulcerated inflamed skin. Therapeutic intervention largely has been unsuccessful, in part due lack known cause for disease. Though exact etiology UD not elucidated, substance P (SP) recently demonstrated as an important neuropeptide linked itch-scratch cycle. SP functions at tachykinin neurokinin 1 (NK1) receptor. We hypothesized that inhibition binding NK1 receptor would decrease itch sensation, thus decreasing scratching behavior subsequent trauma. The purpose this study was evaluate effectiveness antagonist, maropitant citrate, treatment murine UD. Treatment mg/kg citrate significantly reduced size lesions mice.