Vitamin E as a treatment for ulcerative dermatitis in C57BL/6 mice and strains with a C57BL/6 background.

摘要: In this study, we fed a standard NIH-31 diet fortified with vitamin E to C57BL/6 mice and strains of background that had spontaneously developed ulcerative dermatitis (UD). addition the therapeutic response increased levels E, also defined occurrence UD within our facility in terms age, sex, coat color, lesion location on body. Mice spontaneous were E-fortified (3000 IU/kg) for period 8 weeks entered study without regard vendor source, or site number lesions. We found lesions occurred most commonly dorsal cervical scapular regions spared ventral abdomen thorax. No sex color predilection was noted development UD, however males older than females at time development. Of 71 mice, 32 (45%) complete re-epithelialization hair regrowth. Complete repair not influenced by color. The average ranged from 2 5 weeks, there no correlation positive suggests protection oxidative injury may play role resolution offers veterinarians investigators new treatment option ease compliance.