Neonatal severe bacterial infection impairment estimates in South Asia, sub-Saharan Africa, and Latin America for 2010

摘要: Background : Survivors of neonatal infections are at risk neurodevelopmental impairment (NDI), a burden not previously systematically quantified and yet important for program priority setting. Systematic reviews meta-analyses were undertaken applied in three-step compartmental model to estimate NDI cases after severe bacterial infection South Asia, sub-Saharan Africa, Latin America neonates >32 wk gestation (or >1,500 g). Methods: We estimated sepsis, meningitis, pneumonia, or no from among possible ((pSBI) step 1). respective case fatality risks ((CFRs) 2) the survivors (step 3). For tetanus, incidence estimates based on deaths, CFRs, subsequent NDI. results: 2010, we 1.7 million (uncertainty range: 1.1–2.4 million) 200,000 (21,000–350,000) 510,000 (150,000– 930,000) 79,000 (70,000–930,000) tetanus Among survivors, moderate meningitis 23% (95% confidence interval: 19–26%) 18,000 (2,700–35,000) cases, 16% (6–27%), 4,700 (1,700–8,900). conclusion: Data lacking sepsis especially those gestation. Improved recognition treatment pSBI will reduce mortality. Lack follow-up data infections, particularly was striking. Given high even minor would be major public health importance. Prevention infection, improved management, support children with all strategies, currently receiving limited policy attention.