Interactions with Drugs and Dietary Supplements Used For Weight Loss

摘要: Obesity and overweight have increasingly become major global health issues. Data from the World Health Organization (WHO) reports a near doubling of prevalence obesity worldwide 1998 to 2008 [1]. In European Region, an average over 50% adults are nearly 23% obese, with being highest in Finland (67.1%), Germany (67.2%), United Kingdom (67.8%), Malta (73.3%), Greece (77.5%) [2]. Similar alarming trends seen States NHANES data where 68% body mass index (BMI) greater than 25 (overweight or obese) 37% population is considered obese [3-7]. A large burden care costs can be attributed since multiple disease states such as diabetes, cancer, heart linked [8-10]. The WHO estimates that up 6% expenditures while for been estimated at 5.7% National Expenditure [8-11]. Most organizations, like WHO, governmental agencies U.S. Department Agriculture Center Nutrition Policy Promotion focus on treatment epidemic through promotion proper healthy lifestyle changes [11, 12]. Although anti-obesity agents progressed development process, few drug products made it approval process due safety lack efficacy concerns. Several products, amphetamine, fenfluramine sibutramine, had their removed and/or market following linking drugs cardiovascular side effects (e.g. hypertension myocardial infarction), addiction, death [13-15]. As alternative, patients may turn less regulated dietary supplements means assist weight loss. Multiple herbal available indicated, often without significant scientific basis, obesity.