Cytogenetic analysis in renal cell carcinoma: correlation with tumor aggressiveness.

摘要: Twenty-eight tissue specimens from 26 patients with renal cell carcinoma were subjected to cytogenetic analysis using a newly developed combined method of enzymatic technique and short term culture. Of the 28 tumor samples studied, 21 chromosomally abnormal. Four (including two oncocytomas) normal, three did not grow in tumors abnormal chromosomes, most frequent abnormality was either trisomy or tetrasomy chromosome 7 (18 tumors). In four these tumors, only visible abnormality. Ten contained abnormalities 3. Three showed previously reported 3 interstitial deletion, five hyperdiploid, revealed monosomy 10 patients, six have had disease progression, compared one 16 remaining without an These data suggest that represent primary abnormality, when are present association involving 3, they may correlate more aggressive clinical course corresponding higher stage at diagnosis.