Renal cell carcinoma: Cytogenetic analysis of tumors and cell lines

摘要: Successful cytogenetic analysis was performed on 27 samples from 25 patients with RCC, including 7 of 11 tumors studied and 20 cell lines. Clonal chromosomal abnormalities were detected in all samples. The most frequently involved chromosomes 7, 1, 3, 9, the Y (20, 17, 14, 10 cases, respectively). Polysomy or rearrangement 7q seen 80% (20/25) patients, loss 3p 48% (12/25); latter, four had whole chromosome deletions translocations involving 3p, breakpoints at either 3p11-14 3p21-23 (5/7 translocation 3p21-23). Loss sex 15 -Y 10/22 males. Other clonal changes included structural 1 centromere long arm, near 9 (10 patients), polysomy 16, monosomy 20, 22. With exception loss, which primarily confined to nonpapillary no specific abnormality noted for any particular subtype RCC. Trisomy tetrasomy subtypes renal carcinoma.