Renal Cell Carcinoma in Children: A Clinicopathologic Study

作者: Paolo Indolfi , Monica Terenziani , Fiorina Casale , Modesto Carli , Gianni Bisogno

DOI: 10.1200/JCO.2003.02.072

关键词: CarcinomaNephrectomyEl NiñoInternal medicineHistologyMedicineRenal cell carcinomaKidney diseaseStage (cooking)Radiation therapySurgery

摘要: Purpose: To identify the prognostic factors, treatment, and outcome of children affected by renal cell carcinoma (RCC). Patients Methods: The series included 41 patients (18 males 23 females) with a median age 124 months observed at 11 Italian Association for Pediatric Hematology Oncology centers from January 1973 to 2001. Clinical data, surgical notes, pathologic findings, summaries therapy were taken charts. Results: Seven (17%) had papillary histology, 34 (82.4%) nonpapillary histology. Eighteen (43.9%) stage I, one patient (2.4%) II, two (4.8%) IIIA, 10 (24.3%) IIIB, nine (21.9%) IV disease. One bilateral involvement diagnosis. experienced disease recurrence. Lung liver most common distant lesions usually fatal. In this study, major factor influencing prognosis was stage. Event-free ...

参考文章(40)
Joel B. Nelson, Ryoichi Oyasu, Daniel P. Dalton, The Clinical and Pathological Manifestations of Renal Tumors in Von Hippel-Lindau Disease Journal of Urology. ,vol. 152, pp. 2221- 2226 ,(1994) , 10.1016/S0022-5347(17)31646-4
W.P. Zhao, J.R. Gnarra, S. Liu, T. Knutsen, W.M. Linehan, J. Whang-Peng, Renal cell carcinoma: Cytogenetic analysis of tumors and cell lines Cancer Genetics and Cytogenetics. ,vol. 82, pp. 128- 139 ,(1995) , 10.1016/0165-4608(95)00024-J
Ritchie Aw, deKernion Jb, The natural history and clinical features of renal carcinoma. Seminars in Nephrology. ,vol. 7, pp. 131- ,(1987)
Peter Bugert, Christiane Kenck, Gerd Staehler, Gyula Kovacs, Mónica Wilhelm, Terminal Deletion of Chromosome 3p Sequences in Nonpapillary Renal Cell Carcinomas: A Breakpoint Cluster between Loci D3S1285 and D3S1603 Cancer Research. ,vol. 55, pp. 5383- 5385 ,(1995)
Giorgio Pizzocaro, Luigi Piva, Maria Colavita, Sonia Ferri, Raffaella Artusi, Patrizia Boracchi, Giorgio Parmiani, Ettore Marubini, Interferon Adjuvant to Radical Nephrectomy in Robson Stages II and III Renal Cell Carcinoma: A Multicentric Randomized Study Journal of Clinical Oncology. ,vol. 19, pp. 425- 431 ,(2001) , 10.1200/JCO.2001.19.2.425
E. L. Kaplan, Paul Meier, Nonparametric Estimation from Incomplete Observations Springer Series in Statistics. ,vol. 53, pp. 319- 337 ,(1992) , 10.1007/978-1-4612-4380-9_25
Bruce Broeckerker, Renal cell carcinoma in children. Urology. ,vol. 38, pp. 54- 56 ,(1991) , 10.1016/0090-4295(91)80014-X
Manuel D. Carcao, Glenn P. Taylor, Mark L. Greenberg, Mark L. Bernstein, Martin Champagne, Linda Hershon, Sylvain Baruchel, Renal-cell carcinoma in children: a different disorder from its adult counterpart? Medical and Pediatric Oncology. ,vol. 31, pp. 153- 158 ,(1998) , 10.1002/(SICI)1096-911X(199809)31:3<153::AID-MPO5>3.0.CO;2-A