miR-4458 regulates cell proliferation and apoptosis through targeting SOCS1 in triple-negative breast cancer.
作者： Xiaomeng Liu , Jianling Wang , Guochao Zhang
DOI: 10.1002/JCB.28565
关键词:
摘要: Our previous study has suggested suppressor of cytokine signaling 1 (SOCS1) is associated with clinical progression and functions as an oncogenic role to regulate cell proliferation apoptosis in triple-negative breast cancer (TNBC). Several microRNA-messenger RNA (miRNA-mRNA) relationship databases show SOCS1 identified a direct target gene miRNA-4458 (miR-4458). The purpose this was the between miR-4458 TNBC. In our results, expression decreased TNBC tissues cells compared adjacent normal mammary epithelial line, respectively. Moreover, directly bound SOCS1, negatively regulated mRNA protein expression. Furthermore, suppressed promote through regulating Besides, levels patients advanced stage were obviously lower than early stage. conclusion, mediates play tumor-suppressive
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