Quinazolines and azaquinazolines as dual inhibitors of ras/raf/mek/erk and pi3k/akt/pten/mtor pathways
作者： K. THOMPSON , Scott , A. SMITH , Roger , Sanjeeva REDDY
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摘要: The present application provides novel quinazolines and azaquinazolines pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds useful in co-regulating RAS/RAF/MEK/ERK PI3K/AKT/PTEN/mTOR pathways by administering a therapeutically effective amount of one or more the formula (I), wherein X, Y, T R4, R6 to R8' defined herein, patient. By doing so, treating conditions associated with dysregulation pathways. A variety can be treated using include diseases which characterized abnormal cellular proliferation. In embodiment/ disease is cancer.
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