Preparation method of novel substituted pyridine pyrimidine compound
作者： Xu Xuejun , Lin Sheng
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摘要: The invention belongs to the field of pharmaceutical and chemical industry, provides a preparation method novel substituted pyridine pyrimidine compound. compound is great significance medical research new drug development. problem that an amide easily destroyed by strong alkalis in synthesis process under high temperature condition issolved, meanwhile 4-amino group difficult react synthesize due poorer amino activity solved. Moreover, two-step reaction for reducing nitrogroup into hydrolyzing cyano completed one-step reaction, thereby simplifying flow. important support application development future terms conditions, methods processes.
lens.org 参考文章(4)
K. THOMPSON, Scott, A. SMITH, Roger, Sanjeeva REDDY, M. JOHN, Tyler, Kumar NYAVANANDI, Vijay, Hosahalli SUBRAMANYA, Vijay POTLURI, Kumar PANIGRAHI, Sunil, Rao NADIPALLI, Prabhakara, Saumitra SENGUPTA, Quinazolines and azaquinazolines as dual inhibitors of ras/raf/mek/erk and pi3k/akt/pten/mtor pathways ,(2014)
Eduard Dolusic, Ling-Jie Gao, Piet Andre Maurits Maria Herdewijn, Steven Cesar Alfons De Jonghe, Wolfgang Eugen Pfleiderer, Pyrido(3,2-d)pyrimidines and pharmaceutical compositions useful for medical treatment ,(2005)
Xiao-Ling Fan Cockcroft, Sylvie Gomez, Peter Edwards, Keith Allan Menear, Graeme Cameron Murray Smith, Vincent Junior Ming Lai Loh, Marc Geoffrey Hummersone, 2,4-diamino-pyridopyrimidine derivatives and their use as mtor inhibitors ,(2006)
Bian Longxiang, Xu Xuejun, Xie Panpan, Target anti-cancer medicine based on STAT3 (Signal Transducers and Activators of Transcription type 3) protein target spot ,(2017)