Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients.

摘要: Glucagon-like peptide 1 (GLP-1) (7-36 amide) is a physiological incretin hormone that released after nutrient intake from the lower gut and stimulates insulin secretion at elevated plasma glucose concentrations. Previous work has shown even in Type 2 (non-insulin-dependent) diabetic patients GLP-1 retains much of its insulinotropic action. However, it not known whether magnitude this response sufficient to normalize with poor metabolic control. Therefore, 10 unsatisfactory control (HbA1c 11.6 +/- 1.7%) on diet sulphonylurea therapy (in some supplemented by metformin or acarbose), 1.2 pmol x kg-1 min-1 placebo was infused intravenously fasting state (plasma 13.1 0.6 mmol/l). In all patients, (by 17.4 4.7 nmol 1-1 min; p = 0.0157) C-peptide 228.0 39.1 0.0019) increased significantly over basal levels, glucagon reduced -1418 308 min) reached normal concentrations (4.9 0.3 mmol/l) within 4 h administration, but placebo. When were returned towards levels remained stable despite ongoing infusion amide). exogenous an effective means normalizing poorly-controlled patients.(ABSTRACT TRUNCATED AT 250 WORDS)