Glucagon-Like Peptide-1: An Insulinotropic Hormone With Potent Growth Factor Actions at the Pancreatic Islets of Langerhans

摘要: Identification of chemical mediators that support pancreatic (3-cell neogenesis, differentiation, growth, and survival offers the prospect for introduction novel therapeutic strategies in treatment diabetes mellitus. One such mediator is glucagon-like peptide-1 (GLP-1), an intestinally-derived blood glucose-lowering hormone a potential agent use adult-onset mellitus (type 2 diabetes) (1-4). GLP-1 exerts direct action at islets Langerhans to stimulate biosynthesis secretion insulin, thereby lowering levels glucose. Additional effects include stimulation DNA synthesis, increased cellular proliferation, alterations pattern gene expression are critical maintenance fully differentiated 13-cell phenotype. Such growth factor-like GLP- 1 suggest its possible usefulness as stimulus de novo production diabetic subjects, or ex vivo expansion (3-cells isolated purposes transplantation. It also appreciated acts within central nervous system appetite suppressant (5,6). This surprising finding suggests additional beneficial eating disorders, obesity, and/or adipogenic