Glucagon-like peptide-1 Retards Gastric Emptying and Small Bowel Transit in the Rat: Effect Mediated Through Central or Enteric Nervous Mechanisms
作者： Tesfaye Tolessa , Mark Gutniak , Jens Juul Holst , Suad Efendic , Per M Hellstrom
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摘要: This study investigated effects of glucagon-likepeptide-1(7-36)amide (GLP-1) on gastric emptying, smallintestinal transit, and contractility smooth musclestrips in rats. GLP-1 at doses 10 20 pmol/kg/min administered intravenouslydose-dependently retarded transit the small intestine(P < 0.001), while only higher dose 20pmol/kg/min emptying (P 0.01).GLP-1 concentrations up to 10-4 M didnot affect basal tone or thegastrointestinal muscle strips that were stimulated withelectric field stimulation acetylcholine. Our resultsdemonstrate intestinal seems moresensitive than inhibition by GLP-1at physiologic levels plasma. Furthermore, thisinhibition appears be mediated through centralmechanisms rather peripheral actions. Thus,GLP-1 is suggested inhibit an indirect effect viacentral enteric nervous mechanisms.
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