Pegylated lipids and their use for drug delivery
作者： Muthiah Manoharan , Muthusamy Jayaraman , Narayanannair K. Jayaprakash , Martin Maier , David Butler
DOI:
关键词:
摘要: PROBLEM TO BE SOLVED: To provide lipid-therapeutic nucleic acid compositions that encapsulate acids with high efficiency, have drug:lipid ratios, protect the encapsulated from degradation and clearance in serum, are suitable for systemic delivery intracellular of acids.SOLUTION: The problem is solved by poly(ethylene glycol)-lipid conjugates having specific structures.SELECTED DRAWING: None
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