Clinical significance of pathologic subtype in curatively resected ampulla of vater cancer

摘要: Background Ampullary cancer is considered to have a better prognosis than cancers of the distal bile duct and pancreas, recent publications emphasize prognostic importance histologic differentiation intestinal pancreatobiliary types ampullary cancer. The aims this study were identify those factors that affect recurrence after curative resection investigate differences between clinicopathologic features these two pathologic subtypes. Patients Methods The medical records patients underwent pancreatoduodenectomy for carcinoma from February 1995 March 2009 at our institute retrospectively reviewed. One hundred four enrolled in study. pathologist reviewed all reports histopathologic findings. Data on disease free overall survival analyzed. Results The 3- 5-year rates 104 subjects 62.2% 57.7%, respectively, 69.4% 60.1%, respectively. Multivariate analysis showed an advanced T stage (P = 0.049), presence lymph node metastasis (P = 0.003), poor (P = 0.039), type (P = 0.022) significantly increased risk recurrence. Furthermore, was found be more associated with (P = 0.009), regional (P = 0.007), perineural invasion (P = 0.026) type. In addition, subtype Carcinoembryonic antigen (CEA) level important predictors (P = 0.013) types, respectively (P = 0.003). Conclusions An stage, nodal metastasis, differentiation, pancreaticobiliary independent by multivariate analysis. tended present frequently involvement CEA J. Surg. Oncol. 2012; 105:266–272. © 2011 Wiley Periodicals, Inc.