Antipsychotics for aggression in adults: A meta-analysis

摘要: Aggressive behavior complicates the presentation of many psychiatric illnesses, and is associated with significant morbidity. Antipsychotic medications are used to treat this symptom dimension across multiple diagnoses. In meta-analysis we sought identify effect size antipsychotic for treatment reactive-impulsive aggression in adults, differences underlying diagnosis specific agent. A search was conducted four databases, MEDLINE, PsychINFO, Embase Cochrane Library end date August 10, 2016. The terms included "aggression", "irritable mood", "anger", "hostility" "antipsychotic agents" or "dopamine antagonists". 505 results were found, which 47 reviewed detail 21 ultimately analysis. Antipsychotics broadly effective aggression, but sizes similar those non-pharmacologic interventions (standard mean difference=0.29, 95% confidence interval 0.22-0.36, z=8.5, p<0.001). There no evidence according choice agent (χ2=2.7, df=6, p=0.85), conclusive as importance (χ2=3.2, df=3, p=0.36). small dose identified (β=0.0002, CI 0.0001-0.0004, p=0.038). Although antipsychotics appear be their context side-effects should taken into account when making clinical decisions about use.