Hydroxyapatite electret accelerates reendothelialization and attenuates intimal hyperplasia occurring after endothelial removal of the rabbit carotid artery.
作者： Akiko Nagai , Kimihiro Yamashita , Masatoshi Imamura , Hiroshi Azuma
DOI: 10.1016/J.LFS.2008.03.017
关键词:
摘要: The present experiments were designed to investigate whether electrically polarized hydroxyapatite (HA electret) modifies reendothelialization and intimal hyperplasia occurring after endothelial removal of the rabbit carotid artery. Both HA electret non-polarized HA, which served as a control, had been powdered mixed with agarose gel. One two was applied around external surface Histological analyses revealed that but not control significantly inhibited hyperplasia. number Ki67-positive cells detectable in layer fewer group. In group, abundant TUNEL-positive detected media. CD31-positive on luminal higher Endothelium- nitric oxide (NO)-dependent relaxation response carbachol improved only conclusion, this is first report demonstrating by accelerating regeneration functioning enhancing apoptosis medial smooth muscle cells.
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