Viral chemokine receptors and chemokines in human cytomegalovirus trafficking and interaction with the immune system. CMV chemokine receptors.

摘要: The ubiquitous, opportunistic pathogen human cytomegalovirus (CMV) encodes several proteins homologous to those of the host organism. Four different CMV genes encode chemokine receptor-like peptides. These genes, UL33, UL78, US27, and US28, are expressed at various stages infection in vitro. Their functions remain largely unknown. To date, binding signalling has only been demonstrated for US28 gene product. Putative ligands other CMV-encoded receptors discussed on basis phylogenetic analysis. potential roles these virus trafficking, persistence, immune evasion summarized. Similarly, modulation expression chemokines IL-8, MCP-1, MIP-la RANTES relation viral dissemination persistence is reviewed.